Expression of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as other cell functions, has been shown to be a prognostic factor in many cancers, such as esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and hepatocellular carcinoma [5]. This evidence concerns the gene HMGB1 and colorectal cancer.