Overexpression of HMGB1 was significantly correlated with poorer overall survival in esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, hepatocellular carcinoma, nasopharyngeal cancer, head and neck cancer, bladder cancer, cervical cancer, and pleural mesothelioma. This evidence concerns the gene HMGB1 and nasopharyngeal carcinoma.