The risk score was calculated as follows: risk score = 3.13 × (Notch4) ± 1.52 × (p-PKCα/β2) + 0.74 × (XIAP) + 0.58 × (CDK2) + 0.77 × (Akt1) + 0.74 × (TNM stage) + 1.20 × (vascular/lymphatic invasion) + 0.97 × (tumor size) + 0.61 × (age) + 0.58 × (histologic differentiation). Here, NOTCH4 is linked to neoplasm.