Moreover, lymphocytes from X-ALD patients exhibit higher production of NO and cytokines, such as TNF-α and IL-1β, together with overproduction of ROS and the accumulation of the amount of NADPH oxidase gp91 (PHOX) subunit protein, an integral component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex that generates reactive oxygen species in circulating phagocytes and microglia cells [97,98]. The gene discussed is IL1B; the disease is X-linked adrenoleukodystrophy.