Indeed, in AMN patients, the adult form of X-ALD, the spinal cord displayed microglia activation and an increased expression of several phagocytosis-related markers such as Milk Fat Globule-EGF Factor 8 (MFGE8) and TREM2 on viable neurons, which indicates a contribution to neuron degeneration through phagocytosis [152]. Here, MFGE8 is linked to adrenomyeloneuropathy.