NPR1 and cardiac hypertrophy: The authors showed the exacerbation of cardiac hypertrophy and cardiac dysfunction in NPR-A null mice compared to wild-type mice; they also reported that chronic administration of different anti-hypertensive drugs, such as enalapril, furosemide, hydralazine, propranolol, and losartan was not able to reduce cardiac mass in NPR-A KO [75].