In particular, curcumin supplementation (curcumin 1000 mg with 10 mg piperine daily) for 12 weeks was effective on adiponectin increase, whereas the leptin/adiponectin ratio (an index of atherosclerosis degree) and leptin levels decreased independently by the weight loss, reflecting a reduction in the inflammatory TNFα marker [80]. The gene discussed is LEP; the disease is atherosclerosis.