The expression of SETDB1 was significantly increased in NSCLC tissues compared to normal lung tissues (SMD: 0.66; 95% CI: 0.52–0.80; p < 0.001) with moderate heterogeneity (I2 = 54.4%; p < 0.001) (Figure 2A). The gene discussed is SETDB1; the disease is non-small cell lung carcinoma.