TP53 and non-small cell lung carcinoma: However, as shown in Supplementary Figure S3B, a possible trend toward significance showing an association between SETDB1 expression and NSCLC patients carrying mutations for the TP53 gene was observed (SMD: 0.15; 95% CI: −0.004–0.31; p = 0.052), with low heterogeneity (I2 = 0%; p = 0.60).