As many other oncogenes, in certain conditions SETDB1 can participate in tumor suppression: the expression of SETDB1 was significantly decreased in highly metastatic sublines of the CL1 lung cancer cell line (adenocarcinoma) [52], but at the same time SETDB1 mRNA was high in the primary tumor samples in the early stages of NSCLC compared to the advanced stages. This evidence concerns the gene SETDB1 and non-small cell lung carcinoma.