Our results showed that SETDB1 mRNA levels were increased in tissues from NSCLC patients who were current smokers compared to non-smokers (SMD: 0.26; 95% CI: 0.08–0.44; p = 0.004), with low heterogeneity (I2 = 11%; p = 0.33) (Figure 3A). Here, SETDB1 is linked to non-small cell lung carcinoma.