The results of our study demonstrated that TAT HU and HU difference % were independently associated with RFS event after adjusting for age, tumor stage, ER and PR status, ki67 index, maximum SUV, and MTV, suggesting that perceiving the qualitative characteristics of peritumoral breast adipose tissue, as well as primary tumor features, might be of importance for predicting breast cancer recurrence after surgical resection. The gene discussed is ESR1; the disease is breast cancer.