Consistent with the finding on a role of CASC8 in suppression of bladder cancer cell proliferation [21], we observed that HCC cases who carry at least one alternative allele of rs3843549 in CASC8 tend to be protected from developing large-size tumors and against poor functional capacity of the liver (determined by the Child–Pugh grade). Here, CASC8 is linked to hepatocellular carcinoma.