Here, seeking to further characterize the molecular pathogenesis of mucosal melanoma, we explored NRAS and BRAF mutations in mucosal melanoma and compared them to the mutation profiles in cutaneous melanoma and other tumors with mutations in NRAS and BRAF. We discovered that there is very limited data comparing the type of NRAS and BRAF mutations in mucosal and cutaneous melanomas. The gene discussed is NRAS; the disease is mucosal melanoma.