BRAF is commonly mutated in melanomas (50%), papillary thyroid cancers (45%), hairy cell leukemias (100%), and idiopathic disorder Langerhans cell histiocytosis (50–60%), and less frequently in colorectal cancers (10%), lung adenocarcinomas (10%), and hematopoietic and lymphoid tissue malignancies (8%) [40]. Here, BRAF is linked to melanoma.