For example, the R279Q variant of MMP-9 (rs17576 G>A) was reported to be protective against the development of glaucoma in a Caucasian population, and MMP-9 rs3918249 C/C instead of C/T genotype in the promoter region was more frequent in glaucoma and AMD patients [123,124]. This evidence concerns the gene MMP9 and age-related macular degeneration.