Altogether, many studies today point toward a neuroprotective role for LXRs, which makes them good candidates for both molecular diagnosis and strengthens the need for searching NR1H3 and NR1H2 variants responsible for the disease and/or its prognosis, as well as pointing to their future use as pharmacological targets in the treatment of ALS patients. Here, NR1H2 is linked to amyotrophic lateral sclerosis.