In contrast, these same mice expressing caNRF2 in keratinocytes showed mildly reduced tumor incidence and multiplicity in a chemically-induced model of skin cancer, where NRF2-mediated detoxification of the mutagen and of ROS induced during the treatment overruled the pro-tumorigenic activity of NRF2 [72]. This evidence concerns the gene NFE2L2 and skin neoplasm.