An attribute of obesity-related inflammation is enhanced infiltration of macrophages into expanding adipose tissue, activation of specialized immune cells, and secretion of proinflammatory cytokines such as TNF-α, IL-6, and MCP-1 leading to an unresolved inflammatory response, which affects normal metabolism and insulin action [35]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.