For example, lncRNA POIR was found to form a regulatory network with miRNA-182 and FoxO1, which taken a notable up-regulated effect on periodontitis PDLSCs osteogenic differentiation [20] and miR-147 was down-regulated by up-regulation of lncRNA MEG3 to result in increased expression of Sox2, which activated NF-kB pathway and Wnt/β-catenin pathway in PC12 cells after hypoxia [30]. This evidence concerns the gene SOX2 and periodontitis.