Besides, most of researches focusing on lncRNA MEG3 showed that lncRNA MEG3 involved in multifarious cancers was down-regulated in most cancers and affected cell proliferation, progression, and prognosis [28, 29] which indicated there was still a large research space on the influence mechanism of lncRNA MEG3 in periodontitis PDLSCs and our study was of great practical significance. The gene discussed is MEG3; the disease is cancer.