Altogether, the findings presented in this study highlights that lncRNA MEG3 was determined as a biomarker as periodontitis inhibitor because of the new-found mechanism underlying lncRNA MEG3/miR-27a-3p/IGF1 axis via PI3K/Akt signaling pathway by promoting osteogenic differentiation in PDLSCs. The gene discussed is AKT1; the disease is periodontitis.