IgAN is an autoimmune disorder with renal-limited or systemic manifestations (IgA vasculitis or Henoch-Schönlein purpura), determined by a chain of pathogenic events that translates the production of autoantibodies against circulating galactose-deficient IgA1 into subsequent glomerular and tubulointerstitial injury[3,4]. Here, IGHA1 is linked to Henoch-Schoenlein purpura.