The patients with cerebral SVD progression had significantly old age (68.4 ± 8.8 years vs. 62.5 ± 12.8 years), higher prevalence of hypertension (72.4% vs. 53.3%) and lower level of plasma Klotho (251.8 ± 146.3 pg/mL vs. 354.3 ± 202.7 pg/mL) than those without cerebral SVD progression (S3 Table). Here, KL is linked to Hypertension.