Among Akt1+/+ mice, 9 out of 10 mice in the NT group and 10 out of 10 mice in the TH group achieved ROSC, but only 1 mouse survived to 72 h in NT group while 5 out of 10 mice in TH group were alive at 72 h indicating TH confers protection against SCA injury (Fig 1A). The gene discussed is AKT1; the disease is autosomal dominant cerebellar ataxia.