CHEK2 and ovarian cancer: In particular, the missense variants of CHK2 p.Ile157Thr, p.Asp252Gly, c.1100delC, p.His371Tyr, p.Glu161del, p.Ser428Phe, c.591delA, p.Arg117Gly, p.Thr476Met and p.Asp438Tyr were significantly associated with germ-line variants in hereditary breast and ovarian cancer [8–11].