EGR1 and cancer: DT‐13, a saponin of the dwarf lilyturf tuber Ophiopogon japonicus wall (Family: Convallariaceae), possesses anticancer activities against various types of cancers and antiangiogenesis activity 15 on multiple targets, such as early growth response 1 (Egr‐1), VEGF, CCR‐5, HIF‐1α and MMP2/9.16, 17, 18 To increase the efficacy of TPT and avoid the risk of resistance development, we designed combination therapies of DT‐13 and TPT and found that DT‐13 enhanced the pro‐apoptotic effect of TPT on GC by up‐regulating NM IIA/EGFR/Cav‐1 axis.19