Arterial hypertension should be treated according to current guidelines, and therapy should be reintroduced at a reduced dosage after the reduction of arterial hypertension to stage 1 or below.42 In cases of an asymptomatic decrease in LVEF of 10% or more from baseline and below institutional lower limits of normal from pretreatment level, the dosage of BRAF inhibitors should not be modified, but MEK inhibitors should be stopped. The gene discussed is BRAF; the disease is Hypertension.