Furthermore, the observed association of BRAF and MEK inhibitors with arterial hypertension has not been confirmed in studies of BRAF and MEK inhibitors compared with placebo8 or the MEK inhibitor trametinib compared with chemotherapy.14 On the other side, studies of the BRAF inhibitor vemurafenib compared with dacarbasine38 or with placebo39 showed a significant association with arterial hypertension. This evidence concerns the gene MAP2K7 and Hypertension.