MAP2K7 and Hypertension: Treatment with BRAF and MEK inhibitors was associated with an increased risk of a high-grade decrease in LVEF (RR, 2.79; 95% CI, 1.36-5.73; P = .005; I2 = 29%) and high-grade arterial hypertension (RR, 1.54; 95% CI, 1.14-2.08; P = .005; I2 = 0%) (Figure 3).