The measurement of QTc and serum electrolytes is recommended before treatment, after 1 month of treatment, and after any dosage modification made for prolonged QTc.18,42 There are no specific indications for the management of pulmonary embolism, myocardial infarction, or atrial fibrillation, and these should be managed according to the cardiology guidelines, with BRAF and MEK inhibitor treatment considered separately for every individual. Here, MAP2K7 is linked to pulmonary embolism.