In patients with T1D, the observed mean (SD) total daily basal insulin dose (U/day) decreased from 25.0 (14.1) (median 22.0; Q1 to Q3, 16.0 to 30.0) at baseline to 22.8 (13.5) (median 20.0; Q1 to Q3, 15.0 to 27.8) at 12 months (ETD −2.25 U/day; 95% CI, −2.85 to −1.66; P < 0.001) (Fig. 6A). This evidence concerns the gene INS and type 1 diabetes mellitus.