The detachment and migration of tumor cells from the primary location is an important part of lung cancer metastasis, which is closely related to the decrease in adhesion ability between tumor cells, suggesting that knockdown of Syncytin 1 can inhibit the metastasis of NSCLC.24 In addition, Syncytin 1 underexpression also suppressed the expressions of N‐cadherin, β‐catenin, and Vimentin, and promoted the expression of E‐cadherin. The gene discussed is CDH2; the disease is lung cancer.