The result of western blotting proved that Syncytin 1 expression was inhibited by SP1 knockdown (sh‐SP1), which was reversed by Syncytin 1 overexpression (sh‐SP1+ov‐Syncytin 1), indicating that SP1 inhibited Syncytin 1 expression in NSCLC cells (P < .05, Figure 6A,B). Here, ERVW-1 is linked to non-small cell lung carcinoma.