Studies have shown that about 50% to 70% of NSCLC patients have abnormal phosphorylation of Akt and mTOR, which plays an important role in cell proliferation, survival, chemotherapy, and radiotherapy resistance.25 The downstream genes of Akt signaling pathway, Cyclin D1 and P70, were also inhibited by Syncytin 1 knockdown, which further confirmed the signaling pathway by which Syncytin 1 knockdown inhibited the tumor progression. Here, ERVW-1 is linked to neoplasm.