Importantly, a recent study in a mouse model of frontotemporal dementia (Tg4510) showed that treatment with the PERK inhibitor GSK2606414 restored protein synthesis rates, protected against neuronal loss and reduced levels of ER stress markers phospho (p)-PERK, p-eIF2α and ATF4 [12]. The gene discussed is EIF2AK3; the disease is frontotemporal dementia.