The Disease-Associated Microglia (DAM) is characterised by low expression of homeostatic markers (e.g. CX3CR1, P2y12, Tgfb1) and elevated levels of lipid metabolism, phagocytosis, apoptosis, and AD-associated genes (e.g. APOE, Trem2) [15]. This evidence concerns the gene APOE and Alzheimer disease.