We further investigated soluble proinflammatory cytokines in plasma and lung homogenates (IL-1β, KC/GRO, TNFα, IL-6, IL-12p70, and IFNγ) as well as pulmonary influx of myeloid-derived cells 2 weeks into COXi treatment (week 6 of infection). The gene discussed is CXCL1; the disease is infection.