This first cross-disease analysis of the innate gene expression signature of 10 TLRs, 7 key members of the IL1/IL1R family, and interleukin 8 (CXCL8) in peripheral blood mononuclear cells (PBMC) from patients with active SLE, RA, and SSc revealed emerging diversity and abundance in RA compared to SLE and SSc. The gene discussed is IL1B; the disease is rheumatoid arthritis.