In SSc, our study revealed upregulation of IL1RN, IL18, and CXCL8 and downregulation of IL1RAP and IL18R1. In line with our results, upregulated IL1RN mRNA [49], increased IL18 expression in skin biopsies [50], and elevated serum IL8 in patients with scleroderma [51] were reported. Here, IL18 is linked to systemic sclerosis.