This comparison revealed the upregulation of four members of TLR (TLR2, TLR3, TLR5, and TLR8) and six members of the IL1/IL1R family (IL1B, IL1RN, IL1RAP, IL18R1, IL18, and SIGIRR) in RA when compared to healthy controls. The gene discussed is SIGIRR; the disease is rheumatoid arthritis.