In 1995, two mouse models, i.e., Cftrtm2CAM and Cftrtm1KTH, incorporating a deletion of phenylalanine at position 508 (ΔF508) of the Cftr gene locus, the most common genetic mutation associated with human CF, were generated by two separate groups [23, 24]. This evidence concerns the gene CFTR and cystic fibrosis.