To profile molecular signatures of macrophages as they relate to the development of mucoobstructive lung disease, we performed gene expression analyses on purified Scnn1b-Tg+ macrophages at four disease-relevant time-points, i.e., PND 0 (less than 24 hours of age), 3, 10, and 42 [50]. The gene discussed is SCNN1B; the disease is lung disorder.