GLP-1 receptor agonists promote cell proliferation and survival by activating signaling pathways in human islet cells, such as those involving phosphate idylinositol 3 kinase (PI3K) and extracellular regulated kinases 1 and 2 (ERK1/2), which are also frequently activated in human colon cancer cells. Here, GLP1R is linked to malignant colon neoplasm.