The knowledge about circulating concentrations of chemokines RANTES and CCL2 in cardiovascular disease patients is still insufficiently documented, so better understanding of variables that may influence their levels is vital to the field, especially that the inhibition of chemokine-mediated recruitment and activation of monocytes may present a novel therapeutic target to counteract the development and progression of atherosclerotic plaque formation. This evidence concerns the gene CCL2 and cardiovascular disorder.