A new antibody targeting cell membrane-bound and soluble forms of CD73 was recently developed by Innate Pharma (IPH5301), who demonstrated synergistic anti-tumor effects when combined with a novel anti-CD39 antibody (IPH5201) in preclinical mouse models of melanoma and fibrosarcoma (Perrot et al., 2019). This evidence concerns the gene NT5E and fibrosarcoma.