Using microarray technology, Berthier et al. compared transcriptional patterns from kidney tissue of early diabetic disease, progressive kidney disease, and controls (kidney donor tissue and patients with minimal change disease), finding that Janus kinases-signal transducer and activator of transcription (JAK-STAT) signaling pathways are differentially expressed in different kidney tissue compartments (glomerular vs. tubulointerstitial), and at different stages of diabetic kidney disease (early vs. late and progressive) (23). The gene discussed is SOAT1; the disease is diabetic kidney disease.