NRG1 and infection: To examine the effect of NUP98 knockdown during CVB3 infection on the expression of NRG1, ERBB4, PSEN1 and viral capsid protein VP1 (a marker of viral protein synthesis), siRNA targeting NUP98 (siNUP98) or scrambled siRNA was transfected into HeLa cells 48 h prior to infection with CVB3 or sham-infection with PBS.