Additionally, Nup98, Nrg1, and erbB4 were all upregulated in the murine myocardium during acute/early phase of CVB3 infection, and Nrg-1 and erbB4 were downregulated at a later phase of infection, suggesting a cardioprotective role of this signal cascade in cellular response to infection. This evidence concerns the gene NUP98 and infection.