Because five polymorphisms from four genes—SOD2 rs4880, SOD3 rs2536512 and rs2855262, GPX3 rs3828599, and GSTT1 (deletion)—have previously been reported their association with oxidative stress-related CAD risk factors such as HT and T2DM (Hao et al., 2011; Petrovic & Peterlin, 2014; Vats et al., 2015; Yang, Xie & Jin, 2016), they may implicate in lipid abnormalities and severity of coronary atherosclerosis in individuals with CAD. The gene discussed is GPX3; the disease is coronary artery disorder.