The present study, therefore, aimed to evaluate the associations of individual and combined SOD2, SOD3, GPX3, and GSTT1 gene polymorphisms with lipid abnormalities, particularly HTG and low HDL-C level in subjects with high risk of CAD, and to further investigate the associations of these polymorphisms and lipid abnormalities with the severity of coronary atherosclerosis. Here, GPX3 is linked to coronary artery disorder.