The gene acts as an oncogene in colorectal cancer because CLEC3B is secreted by cancer-associated fibroblasts promotes tumor cell migration (Zhu et al., 2019), whereas it could inhibit clear cell renal cell carcinoma proliferation via mitogen-activated protein kinase (MAPK) pathway (Liu et al., 2018). The gene discussed is CLEC3B; the disease is colorectal cancer.