In the setting of insulin resistance, systemic cytokine elevations (including IL-6) have been implicated in acute-phase response (C-reactive protein) induction, heightened endothelial production of vascular cell adhesion molecule 1 (VCAM-1) and monocyte chemotactic protein 1 (MCP-1), and consequently the development of macrovascular disease [33]. The gene discussed is VCAM1; the disease is Insulin resistance.