CD4 and tuberculosis: BCG85B induces robust CD4 and CD8 T-cell responses in mice.14 To determine the antigen specificity of BCG-induced T cells mediating protection against tuberculosis, T cells were phenotyped using three well-characterized CD8 tetramers along with an MHC-II tetramer for Ag85B (NIH core tetramer facility, Emory University, USA).