C5 and tuberculosis: rBCG30) enables secretion of Ag85B in copious quantities, which induces aggresome-dependent autophagy and enhances efficacy against tuberculosis in mice.14 Since rBCG30 ( = BCG85B) has undergone human trials, and could potentially replace wt-BCG53,54; we sought to further increase the efficacy of the BCG85B vaccine through expression of C5 peptide.