Since TB10.4+ CD8 T cells are associated with protection against tuberculosis in mice, these data confirm the superior efficacy of BCG85C5 and its dependence on TLR-2.57 Finally, the lungs of vaccinated mice contained elevated levels of Ag85B-specific CD4 T cells and MFCs (Fig. 6j, k). The gene discussed is TMSB10; the disease is tuberculosis.