The antigens of the panel of six TAAbs they used were p53, NY-ESO-1, CAGE, GBU4-5, Annexin I, and SOX2, p53 is a tumor suppressor gene, which is the most frequently mutated gene in cancer (in addition to LC, it still can be found in breast cancer etc.72), indicating that it plays a crucial role in preventing cancer formation73. This evidence concerns the gene ANXA1 and cancer.