In conclusion, our data in rats with stablished MetS-induced FAT diet for 13 weeks and orally treated with HPβCD/Ang-(1-7) in the last six weeks show that Ang-(1-7) was efficient in normalizing lipid metabolism, improving the insulin signaling pathway in the liver and gastrocnemius muscle, function, and macrovesicular liver damage, probably by restoring the unbalance between RAS axis and reducing oxidative stress in the liver and gastrocnemius muscle. This evidence concerns the gene INS and metabolic syndrome.