We have shown that dietary supplementation with SkQ1 starting at the preclinical stage of AD-like pathology (at age 1.5 months) reduces the age-related alterations in behavior and the spatial memory deficit and slows down pathological accumulation of Aβ and hyperphosphorylation of tau protein in 23-month-old OXYS rats [11]. Here, MAPT is linked to Alzheimer disease.