They found that serum MMP-3 levels were significantly higher in SLE patients with active clinical presentation such as persistent proteinuria, malar rash, and laboratory parameters, such as cellular casts, anti-dsDNA antibodies, decreased complement C3 and C4 levels, circulating immune complexes, and hypoalbuminemia [2]. The gene discussed is MMP3; the disease is systemic lupus erythematosus.