However, CSF3R and CSF3 gene expression changes were opposite to each other: while their expression increased in NB4 and HL60 cells, it significantly decreased in APL patient blasts (Figure 3(b)). CSF3 codes for the granulocyte colony-stimulating factor (G-CSF); CSF3R codes its receptor. This evidence concerns the gene CSF3 and acute promyelocytic leukemia.