As the first line of host defense against viral infection, host pattern recognition receptors (PRRs), including RLRs, toll-like receptors (TLRs), and cytosolic dsDNA sensors (such as STING), recognize viral nucleic acids inducing innate immune responses, resulting in the production of type I interferons (IFNs) and proinflammatory cytokines [23, 24]. The gene discussed is STING1; the disease is viral infectious disease.