IARS1 and Intellectual disability: Two genes represented the catalytic activity category (GO:0003824) (Figure 4B)—IARS (isoleucyl-tRNA synthetase), involved in amino acid metabolism, and mutations in this gene have been associated with intellectual disability (Kopajtich et al., 2016), and OXSR1 (oxidative stress–responsive 1), which belongs to Ser/Thr protein kinase family which regulates downstream kinases in response to environmental stress and is overexpressed in schizophrenia (Arion and Lewis, 2011).