IFNG and cytomegalovirus infection: Studies of functional gene polymorphisms in pro-inflammatory and anti-inflammatory cytokines with HCMV disease identified IFNG (interferon-gamma) +874 A/T polymorphism as a risk factor for HCMV disease in kidney and lung transplant patients, where the +874 A allele, a low IFNG producer (reduced gene expression), is associated with increased risk for HCMV infection and disease after organ transplantation (Mitsani et al., 2011; Vu et al., 2014).