In a cohort of solid organ transplant patients from Alberta, a functional single nucleotide polymorphism (SNP) (rs8099917) associated with lower INFL3 (IL-28B) expression during CMV infection, but higher IFN-stimulated gene expression showed a protective effect against CMV replication (Egli et al., 2014). The gene discussed is IFNA1; the disease is cytomegalovirus infection.