For example T, B, and NK specific subset phenotyping panels can pick up ALPS (increased double negative T cells), X-linked agammaglobulinemia due to mutations in BTK (low B cell counts or BTK expression), mutations in CD27 (absent surface expression of CD27), mutations in MAGT1 (lowered NKG2D expression), and a variety of SCID disorders (very low B, T, and/or NK counts, reduced recent thymic emigrants and CD45RA expression) (95). Here, BTK is linked to severe combined immunodeficiency.