Blood T cells from patients with chronic osteomyelitis show increased expression of LAG-3 and impaired proliferation/function. Hence, LAG-3 blockade can increase T cell activation in chronic implant-related bone infections. An early Th2/Treg immunity was shown to prevent biofilm formation and chronicity in a murine orthopedic implant infection model. TIGIT treatment at an early time point can be supportive to clear infections via induction of a Th2-based T cell response. Here, LAG3 is linked to infection.