STAT3 and neoplasm: Zhang et al. demonstrated another immunostimulatory function of STING in a nasopharyngeal carcinoma model whereby it inhibited the phosphorylation of signal transducer and activator of transcription 3 (STAT3) in both tumor and myeloid cells through suppressor of cytokine signaling 1 (SOCS1), an intracellular STAT inhibitor (69).