TP53 and neoplasm: It should be emphasized in this regard that the administration of IFN-β leads to increased cellular senescence in keratinocytes through the regulation of JAK/STAT-induced PML and p53, enhances p53-dependent senescence in fibroblasts, and also induces genotoxic drug-mediated senescence through JAK/STAT-mediated PML induction in tumor cells (7, 17, 19, 20).