KLF4 and B-cell chronic lymphocytic leukemia: qRT-PCR analysis showed in CLL treated mice (Figures 1E,F), a downregulation of genes encoding for endothelial surface proteins (CD31, Cdh5, CD34), for signaling molecules (Notch4, Flt4, Jag2) (32), and transcription factors (TCF4 and KLF4) (44, 45) involved in endothelial differentiation.