The monocyte/macrophage depletion efficiency, as assessed by measuring the fraction of CD11b+ and F4/80+ cells in peripheral blood of CLL- and Sham- treated mice by flow cytometric analysis, was comparable to our previous studies (Figure 1B, Supplementary Figures S1A,B) (16, 40). The gene discussed is ITGAM; the disease is B-cell chronic lymphocytic leukemia.