RA-FLSs usually secret various proinflammatory cytokines and chemokines, especially IL-6, IL-8, IL-1β, TNF-α, and IL-17 to recruit and activate more immune cells to the inflammatory microenvironment, and thereby are responsible for cartilage damage and joint destruction (39, 40). Here, CXCL8 is linked to rheumatoid arthritis.